| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932636 | Developmental Biology | 2011 | 11 Pages |
Abstract
⺠Lens epithelial cells proliferate in the absence of E2F1-3 during development. ⺠Loss of E2F1-3 alters expression of genes required for lens differentiation. ⺠E2F loss causes activation of p53 signaling, DNA double-strand breaks and apoptosis. ⺠Cell cycle-dependent genes are upregulated with ablation of E2F “activators”. ⺠Deletion of E2F3 rescues hallmark phenotypic defects caused by loss of Rb.
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Authors
Pamela L. Wenzel, Jean-Leon Chong, M. Teresa Sáenz-Robles, Antoney Ferrey, John P. Hagan, Yorman M. Gomez, Ravi Rajmohan, Nidhi Sharma, Hui-Zi Chen, James M. Pipas, Michael L. Robinson, Gustavo Leone,