Article ID Journal Published Year Pages File Type
10932642 Developmental Biology 2011 9 Pages PDF
Abstract
►Pax8 and Sox3 are initially coinduced in the otic placode by hindbrain Fgf. ►Pax8 promotes otic development by autonomously downregulating foxi1. ►Pax8 also induces otic expression of fgf24, which locally downregulates sox3. ►Fgf24 also induces epibranchial development by activating sox3 in adjacent ectoderm.
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