Article ID Journal Published Year Pages File Type
10932664 Developmental Biology 2011 17 Pages PDF
Abstract
► Six1 is expressed in lung distal epithelium and mesenchyme. ► Six1−/− lungs are hypoplastic with reduced branching. ►Six1 controls both epithelial and mesenchymal cell proliferation. ► Six1 induces epithelial progenitor cell proliferation but inhibits differentiation. ► Six1 coordinates Shh-Fgf10 signaling during lung development.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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