Article ID Journal Published Year Pages File Type
10932680 Developmental Biology 2011 9 Pages PDF
Abstract
► Mdm2 regulates p53 levels and activity in skin. ► Loss of Mdm2 induces p53-mediated senescence in the epidermal stem cell compartment. ► This reduces epidermal stem cell function and causes premature aging skin phenotypes.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin
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