The Notch effector gene Hes1 regulates migration of hypothalamic neurons, neuropeptide content and axon targeting to the pituitary

►Hes1 alone does not affect cell proliferation or death in developing diencephalon. ►Hes1 may be necessary for proper boundary formation of AVP neurons to PVN and SON. ►Hes1 null mice exhibit abnormal AVP and SS axonal projection to the pituitary. ►Hes1 null pituitaries have aberrant SS peptide content.