Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene

► Krüppel-like factor 4 (Klf4) regulates intestinal epithelial homeostasis. ► Deletion of Klf4 increases rates of proliferation of intestinal epithelial cells. ► Deletion of Klf4 prevents differentiation of goblet cells. ► Deletion of Klf4 results in mispositioning of Paneth cells. ► Intestine-specific deletion of Klf4 leads to activation of Wnt pathway.