| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932774 | Developmental Biology | 2011 | 11 Pages |
Abstract
⺠We studied the role of Ngn3 in the development of mouse ventral hypothalamic neurons. ⺠Ngn3+ neural progenitors contribute to NPY+, POMC+, SF1+ and TH+ neuronal populations. ⺠Reduced and increase numbers of POMC+ and NPY+ neurons respectively in Ngn3-/- embryos. ⺠No change in proneural gene expression or total cell number in Ngn3-/- embryos. ⺠Ngn3 plays a central role in the generation of neurons controlling energy balance.
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Authors
Michelle Pelling, Neal Anthwal, David McNay, Gerard Gradwohl, Andrew B. Leiter, Francois Guillemot, Siew-Lan Ang,