| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10932793 | Developmental Biology | 2011 | 9 Pages |
Abstract
⺠Endothelial cells express only talin1 and not the highly related talin2. ⺠Inactivation of the talin1 gene in the embryo results in a rapid onset angiogenesis defect. ⺠Tln1 null endothelial cells in vivo are unable to form lumen-containing vessels. ⺠Talin1 and integrin-mediated adhesion are required from the earliest stages of angiogenesis.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Susan J. Monkley, Vassiliki Kostourou, Lorraine Spence, Brian Petrich, Stacey Coleman, Mark H. Ginsberg, Catrin A. Pritchard, David R. Critchley,