| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10933050 | Developmental Biology | 2010 | 8 Pages |
Abstract
The nonmuscle myosin II NMY-2 is required for cytokinesis as well as for the establishment of zygote asymmetry during embryogenesis in Caenorhabditis elegans. Here we describe two conditional nmy-2 alleles that rapidly and reversibly inactivate the protein. We show that NMY-2 has late-cell-cycle roles in maintaining embryonic asymmetries and is also required for a surprisingly late step in the maintenance of the cytokinesis furrow. Finally, during a signaling-induced asymmetric cell division, NMY-2 is required for SRC-dependent phosphotyrosine signaling and acts in parallel with WNT-signaling to specify endoderm.
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Authors
Ji Liu, Lisa L. Maduzia, Masaki Shirayama, Craig C. Mello,