Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10933802 | Developmental Biology | 2006 | 17 Pages |
Abstract
These findings indicate that a PDZ domain protein is important for normal somite formation and in normal heart development. Treatment of zebrafish embryos with cyclopamine, which disrupts hedgehog signaling, abolished cypher expression in 9 somite and 15-somite stage embryos. Taken together, our data suggest that cypher may play a role downstream of sonic hedgehog, in a late stage of somite development, when slow muscle fibers differentiate and migrate from the adaxial cells.
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Authors
David L.M. van der Meer, Ines J. Marques, Jelani T.D. Leito, Jaya Besser, Jeroen Bakkers, Edwige Schoonheere, Christoph P. Bagowski,