Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10934259 | Developmental Biology | 2005 | 13 Pages |
Abstract
Through an unusual differentiation process, human trophoblast progenitors (cytotrophoblasts) give rise to tumor-like cells that invade the uterus. By an unknown mechanism, invasive cytotrophoblasts exhibit permanent cell cycle withdrawal. Here, we report molecular cytogenetic data showing that â¼20 to 60% of these interphase cells had acquired aneusomies involving chromosomes X, Y, or 16. The incidence positively correlated with gestational age and differentiation to an invasive phenotype. Scoring 12 chromosomes in flow-sorted cytotrophoblasts showed that more than 95% of the cells were hyperdiploid. Thus, aneuploidy appears to be an important component of normal placentation, perhaps limiting the proliferative and invasive potential of cytotrophoblasts within the uterus.
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Authors
Jingly F. Weier, Heinz-Ulrich G. Weier, Christine J. Jung, Matthew Gormley, Yan Zhou, Lisa W. Chu, Olga Genbacev, Alexi A. Wright, Susan J. Fisher,