Article ID Journal Published Year Pages File Type
10939468 Fungal Genetics and Biology 2012 12 Pages PDF
Abstract
► Mtl1 is a sensor highly O-mannosylated by the O-mannosyltransferases Pmt2, Pmt1 and Pmt4 in Saccharomyces cerevisiae. ► O-mannosylation is important in the oxidative response and upon TOR blockade. ► Mtl1 physically interacts with Rom2 (a GTP exchange factor for Rho1). ► The absence of both Pmt2 and Pmt1 make cells sensitive to rapamycin and hydrogen peroxide. ► Mtl1 stability is influenced by both Pmt1 and Pmt2.
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