Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10939484 | Fungal Genetics and Biology | 2011 | 9 Pages |
Abstract
⺠In this study we show how the L98H substitution confers to MAR in Aspergillus fumigatus ⺠The capacity of the entry channels is narrowed and binding of azoles is obstructed. ⺠Site-directed mutagenesis correlate the TR/L98H mutations to azole resistance. ⺠Codon 98 is highly conserved and important for maintaining the CYP51A structure.
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Authors
Eveline Snelders, Anna Karawajczyk, Rob J.A. Verhoeven, Hanka Venselaar, Gijs Schaftenaar, Paul E. Verweij, Willem J.G. Melchers,