Article ID Journal Published Year Pages File Type
10939484 Fungal Genetics and Biology 2011 9 Pages PDF
Abstract
► In this study we show how the L98H substitution confers to MAR in Aspergillus fumigatus ► The capacity of the entry channels is narrowed and binding of azoles is obstructed. ► Site-directed mutagenesis correlate the TR/L98H mutations to azole resistance. ► Codon 98 is highly conserved and important for maintaining the CYP51A structure.
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Authors
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