| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10939530 | Fungal Genetics and Biology | 2011 | 8 Pages |
Abstract
⺠We constructed deletions of the checkpoint proteins Mec1 and Sgs1 in C. albicans. ⺠The SGS1 mutant is sensitive to more DNA-damaging agents than the MEC1 mutant. ⺠The MEC1 mutant exhibits more genome instability than the SGS1 mutant. ⺠Neither deletion influences the frequency of antifungal drug resistance. ⺠Our data constrain the models linking genome instability and drug resistance.
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Authors
Melanie Legrand, Christine L. Chan, Peter A. Jauert, David T. Kirkpatrick,