Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10940274 | Gene Expression Patterns | 2005 | 8 Pages |
Abstract
The Evi-1 gene was first identified as a site for viral integration in murine myeloid leukemia. Evi-1 is a zinc finger transcription factor that has been implicated in the development of myeloid neoplasia. In humans, disruption of the Evi-1 locus, by chromosomal rearrangements, is associated with myeloid leukemia and myelodyplastic syndromes. Here, we report the cloning and developmental pattern of expression of Xenopus Evi-1. xEvi-1 is expressed during oogenesis and during embryonic development. In situ hydridization reveals that xEvi-1 has a dynamic expression profile during early embryonic development. Expression of Evi-1 is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck.
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Authors
Paul E. Mead, Evan Parganas, Shiro Ohtsuka, Kazuhiro Morishita, Laura Gamer, Emin Kuliyev, Christopher V.E. Wright, James N. Ihle,