| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10940660 | Immunobiology | 2016 | 7 Pages |
Abstract
The complement system plays a key role in host-defense against common pathogens but must be tightly controlled to avoid inflammation and tissue damage. Polymorphisms in genes encoding two important negative regulators of the alternative complement pathway, complement factor H (CFH) and complement factor I (CFI), are associated with the risk for Age-Related Macular Degeneration (AMD), a leading cause of vision impairment in the ageing population. In this review, we will discuss the genetic basis of AMD and the potential impact of complement de-regulation on disease pathogenesis. Finally, we will highlight recent therapeutic approaches aimed at controlling complement activation in patients with AMD.
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Authors
Menno van Lookeren Campagne, Erich C. Strauss, Brian L. Yaspan,