Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10940870 | Immunobiology | 2015 | 24 Pages |
Abstract
Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3â786C allele and â786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2â277 G allele and â277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red-ox stress pathway could augment the risk in NPC-susceptible individuals.
Keywords
NOS3NOS2NOS1GSTsNPCLPSVNTRRFLPRNSNOSneuronal NOSinducible NOSROSendothelial NOSVariable number of tandem repeatOxidative stressTunisialipopolysaccharideodds ratioNitric oxidenitric oxide synthasepolymerase chain reactionPCRPolymorphismrestriction fragment length polymorphismSingle nucleotide polymorphismSNPNasopharyngeal carcinomaglutathione S-transferasesNitrogen speciesReactive oxygen species
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Authors
Arij Ben Chaaben, Christina Mariaselvam, Sofiane Salah, Marc Busson, Nicolas Dulphy, Hayet Douik, Abderraouf Ghanem, Wahid Boukaouci, Reem Al Daccak, Tesnim Mamoghli, Latifa Harzallah, Jihene Bouassida, Catherine Fortier, Said Gritli,