Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10941104 | Immunobiology | 2012 | 17 Pages |
Abstract
Factor H (FH) is the major plasma regulator of the central complement protein C3b in the alternative pathway of complement activation. The elucidation of the FH interactions with five major ligands (below) is complicated by their weak μM dissociation constants KD and FH multivalency. We present the first survey of all the KD values for the major FH-ligand interactions and critically review their physiological significance.
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Authors
Stephen J. Perkins, Ruodan Nan, Keying Li, Sanaullah Khan, Ami Miller,