| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953727 | Journal of Molecular and Cellular Cardiology | 2015 | 39 Pages |
Abstract
Exenatide increased contractility in a dose-dependent manner via GLP-1R/cAMP/PKA pathway and induced GLUT-1 and Epac2 translocation in human atrial myocardium, but had no effect in ventricular myocardium. Therapeutic use of GLP-1R-agonists may therefore impart beneficial effects on myocardial function and remodelling.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Markus Wallner, Ewald Kolesnik, Klemens Ablasser, Mounir Khafaga, Paulina Wakula, Senka Ljubojevic, Eva Maria Thon-Gutschi, Harald Sourij, Martin Kapl, Nicholas J. Edmunds, J. Brent Kuzmiski, David A. Griffith, Igor Knez, Burkert Pieske,