| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953748 | Journal of Molecular and Cellular Cardiology | 2012 | 8 Pages |
Abstract
⺠BALB/c mice have brain serotonin dysfunction due to a SNP in tryptophan hydroxylase 2. ⺠Knock-in mice bearing a sarcomeric protein mutation that causes DCM were created. ⺠BALB/c mice, but not C57Bl/6 mice, developed severe congestive heart failure (HF). ⺠Drugs to increase brain serotonin function ameliorated HF in BALB/c mice. ⺠Brain serotonin may play an important role in the development of congestive HF in DCM.
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Authors
Lei Li, Sachio Morimoto, Sachiko Take, Dong-Yun Zhan, Cheng-Kun Du, Yuan-Yuan Wang, Xue-Li Fan, Tatsuya Yoshihara, Fumi Takahashi-Yanaga, Toshihiko Katafuchi, Toshiyuki Sasaguri,