| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953766 | Journal of Molecular and Cellular Cardiology | 2012 | 6 Pages |
Abstract
⺠SIRT3 is a mitochondrial enriched protein lysine residue deacetylase. ⺠Deacetylation of mitochondrial proteins modifies target protein function. ⺠SIRT3 target proteins control mitochondrial energetics and ROS levels. ⺠SIRT3 ameliorates pressure-overload and aging associated cardiac dysfunction.
Keywords
CREBPGC-1Cyclophilin DSirt3ALDH2NMNNAMPTGcn5-related N-acetyltransferaseLCADMnSODMPTPTMHDACTCAAMPKNmnatROSTip60adenosine monophosphate kinasealdehyde dehydrogenase 2tricarboxylic acidPost translational modificationmitochondrial permeability transitionmanganese superoxide dismutaseMitochondriaNADnicotinamide adenine dinucleotidenicotinamide phosphoribosyltransferasenicotinamide mononucleotideHistone acetyltransferasehistone deacetylaseCardiac hypertrophycyclic AMP response element binding proteinHATGNATReactive oxygen species
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Authors
Michael N. Sack,