Back to your heart: Ubiquitin proteasome system-regulated signal transduction

Article ID	Journal	Published Year	Pages	File Type
10953767	Journal of Molecular and Cellular Cardiology	2012	12 Pages	PDF

Abstract

âº The ubiquitin proteasome system (UPS) regulates signal transduction in the heart âº The UPS regulates JNK, calcineurin, FOXO, p53, and estrogen receptor signaling in relevant models of cardiac disease âº Regulation of the UPS can influence outcomes in cardiac hypertrophy, heart failure, ischemia, and diabetic cardiomyopathy âº The UPS affects cardiac signal transduction pathways significant to cardiac health and disease.

Keywords

MKP-1 MAPK phosphatase 1 Ubiquitin specific protease TIGAR GSK3β Ubc9 CBP COP1 AP-1 Fbw7 Hsp E6-associated protein TP53-induced glycolysis and apoptosis regulator TAC USP E6-AP NFAT MEKK1 MuRF1 Hausp Jnk p53 Ubiquitin activating enzyme DBD LBD Muscle RING finger-1 Muscle atrophy F-box DCM SUMO ERα/β ataxia telangiectasia mutated c-Jun N-terminal kinase I/R MAPK Mdm2 ubiquitin conjugating enzyme Myocardial infarction Akt Ischemia Ischemia reperfusion Diabetes forkhead box c-Jun ATM DNA binding domain ligand binding domain murine double minute 2 Ubiquitin proteasome system Nuclear Factor of Activated T Cells FoxO Cardiac hypertrophy Proteasome CREB binding protein tumor protein 53 Heat shock protein activator protein 1 protein kinase B mitogen activated protein kinase mitogen-activated protein kinase kinase kinase CHiP Dilated cardiomyopathy Calcineurin small ubiquitin-like modifier Estrogen receptor UPS Ubiquitin