| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953781 | Journal of Molecular and Cellular Cardiology | 2012 | 7 Pages |
Abstract
⺠We studied the effects of a soluble epoxide hydrolase inhibitor in heart failure rats. ⺠The inhibitor induced an increase in epoxyeicosatrienoic acid bioavailability. ⺠This was associated with an improvement in systolic and diastolic cardiac function. ⺠Enhanced cardiac perfusion and reduced oxidative stress contributed to this effect. ⺠This pharmacological strategy represents a promising approach to treat heart failure.
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Authors
Nassiba Merabet, Jeremy Bellien, Etienne Glevarec, Lionel Nicol, Daniele Lucas, Isabelle Remy-Jouet, Frederic Bounoure, Yvonne Dreano, Didier Wecker, Christian Thuillez, Paul Mulder,