| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953785 | Journal of Molecular and Cellular Cardiology | 2012 | 10 Pages |
Abstract
⺠PGC-1α is necessary for mitochondrial biogenesis in the insulin resistant heart. ⺠PGC-1β is responsive to insulin resistance and has an overlapping role with PGC-1α. ⺠Deficiency of both PGC-1 isoforms impairs mitochondrial function.
Keywords
GTTTAGNoRCIVCTOCRPGC-1ECHOERRPPAROXPHOSAUCFatty acidFatty acid oxidationechocardiogramleft ventricleDiabetesTriacylglycerideglucose tolerance testFAOOxidative phosphorylationMetabolismInsulin resistancearea under the curveMitochondriaOxygen consumption rateElectron microscopyKnockdownheart failurewild-typehigh fatCardiomyopathyperoxisome proliferator-activated receptorEstrogen related receptor
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Authors
Riddhi Mitra, Daniel P. Nogee, Juliet F. Zechner, Kyungmoo Yea, Carrie M. Gierasch, Attila Kovacs, Denis M. Medeiros, Daniel P. Kelly, Jennifer G. Duncan,