| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953786 | Journal of Molecular and Cellular Cardiology | 2012 | 7 Pages |
Abstract
⺠Excessive stress is a potent inductor of cardiomyocyte apoptosis and remodelling. ⺠miR-20a is upregulated in acute biomechanical stress as well as hypoxia. ⺠miR-20a significantly inhibited hypoxia-mediated apoptosis. ⺠miR-20a's antiapoptotic effect appears to be mediated through targeting of Egln3. ⺠This study reveals miR-20a as a novel cardioprotective microRNA.
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Authors
Derk Frank, Johanne Gantenberg, Inka Boomgaarden, Christian Kuhn, Rainer Will, Kai-Uwe Jarr, Matthias Eden, Kristin Kramer, Mark Luedde, Heimo Mairbäurl, Hugo A. Katus, Norbert Frey,