| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953799 | Journal of Molecular and Cellular Cardiology | 2012 | 7 Pages |
Abstract
⺠HCN2 was co-expressed with Adenylyl Cylase 1 (AC1) or 6 (AC6) in cardiac myocytes. ⺠AC1 but not AC6 increased [cAMP]i, accelerated beating rate and shifted HCN2 positive. ⺠In both AC1 and AC6 groups, isoproterenol shifted HCN2 activation relation positive. ⺠BAPTA prevented the isoproterenol effect in the AC1 but not AC6 group. ⺠AC1 plays a key role in sensitivity of β-adrenergic stimulation of HCN to [Ca]i.
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Authors
Yelena N. Kryukova, Lev Protas, Richard B. Robinson,