| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953800 | Journal of Molecular and Cellular Cardiology | 2012 | 9 Pages |
Abstract
⺠Reduced Na and Ca transport but unaltered [Na]i and diastolic [Ca]i in AnkB+/â myocytes. ⺠Ca transients, SR Ca load and fractional SR Ca release are larger in AnkB+/â myocytes. ⺠Higher Ca spark frequency and unaltered total SR Ca leak in intact AnkB+/â myocytes. ⺠The bias towards Ca spark-mediated leak is due to different cytosolic RyR regulation. ⺠More coordinated RyR openings increase the propensity for Ca waves in AnkB+/â mice.
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Authors
Emmanuel Camors, Peter J. Mohler, Donald M. Bers, Sanda Despa,