Article ID Journal Published Year Pages File Type
10953801 Journal of Molecular and Cellular Cardiology 2012 8 Pages PDF
Abstract
► Bone marrow derived mesenchymal stem cells enhance cardiomyocyte E-CC. ► Changes in E-CC and survival are mediated by paracrine signaling. ► MSCs activate the PI3K/Akt pathway and eNOS dependent NO production. ► MSCs increase Ca transient amplitude by increasing ICa,L and SERCA activity. ► Increased SERCA activity depends on eNOS activity.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
Preview
Excitation-contraction coupling in ventricular myocytes is enhanced by paracrine signaling from mesenchymal stem cells
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