| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953802 | Journal of Molecular and Cellular Cardiology | 2012 | 8 Pages |
Abstract
⺠Protein tyrosine phosphatase 1B inhibition (PTP1Bi) was assessed in heart failure. ⺠PTP1Bi or gene deficiency reduced adverse LV remodeling, and improved LV function. ⺠PTP1Bi of gene deficiency reduced cardiac fibrosis and hypertrophy. ⺠PTP1Bi or gene deficiency restored endothelial function. ⺠PTP1B may be a new therapeutic target in CHF.
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Authors
Elodie Gomez, Magali Vercauteren, Baptiste Kurtz, Antoine Ouvrard-Pascaud, Paul Mulder, Jean-Paul Henry, Marie Besnier, Aurélie Waget, Rob Hooft Van Huijsduijnen, Michel L. Tremblay, Remy Burcelin, Christian Thuillez, Vincent Richard,