Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice

Article ID	Journal	Published Year	Pages	File Type
10953807	Journal of Molecular and Cellular Cardiology	2012	9 Pages	PDF

Abstract

âº Absence of left ventricular hypertrophy in heterozygous Mybpc3-targeted knock-in mice. âº Myofilament Ca2+ sensitization in heterozygous Mybpc3-targeted knock-in mice. âº Diastolic dysfunction independent of left ventricular hypertrophy. âº Hypertrophic cardiomyopathy as a model of diastolic heart failure.

Keywords

HCM LVH cTnI cMyBP-c Cardiac myosin-binding protein C CSQ HET cardiac troponin I Left ventricular hypertrophy Hypertrophic cardiomyopathy Calsequestrin

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology

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Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice

Authors

Bodvaël Fraysse, Florian Weinberger, Sonya C. Bardswell, Friederike Cuello, Nicolas Vignier, Birgit Geertz, Jutta Starbatty, Elisabeth Krämer, Catherine Coirault, Thomas Eschenhagen, Jonathan C. Kentish, Metin Avkiran, Lucie Carrier,