| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953819 | Journal of Molecular and Cellular Cardiology | 2012 | 12 Pages |
Abstract
⺠Calcineurin is activated in subcellular domains by high local calcium and contact with targets. ⺠In a sarcolemmal microdomain calcineurin dephosphorylates NFAT which translocates to the nucleus. ⺠Calcineurin itself translocates to the nucleus to enhance NFAT dependent prohypertrophic effects. ⺠Calcineurin dephosphorylates MEF2 in vicinity to the SR or Drp1 and Bad in association with mitochondria.
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Authors
Joerg Heineke, Oliver Ritter,