| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953826 | Journal of Molecular and Cellular Cardiology | 2012 | 12 Pages |
Abstract
⺠SOCE is abundant and robust in neonatal cardiomyocytes, yet absent from adult. ⺠STIM1 is a required element in the activation of SOCE. ⺠STIM1 expression - including a novel splicing isoform - is re-activated by stress. ⺠STIM1-dependent SOCE activates the calcineurin-NFAT signaling pathway. ⺠STIM1-dependent SOCE is a critical element in pathological hypertrophy.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Xiang Luo, Berdymammet Hojayev, Nan Jiang, Zhao V. Wang, Samvit Tandan, Andrey Rakalin, Beverly A. Rothermel, Thomas G. Gillette, Joseph A. Hill,