| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953828 | Journal of Molecular and Cellular Cardiology | 2012 | 11 Pages |
Abstract
⺠Cardiac myosin binding protein-C (cMyBP-C) is an easily releasable sarcomeric protein. ⺠Dephosphorylation of cMyBP-C is directly correlated with its degradation in vitro and in vivo. ⺠cMyBP-C and N-terminal fragments are released into the blood post-myocardial infarction. ⺠Established a sandwich ELISA to quantify concentration of plasma cMyBP-C. ⺠Plasma concentrations of cMyBP-C could be a potential biomarker for myocardial infarction.
Keywords
PBSMyosin binding protein-Ccardiac myosin binding protein-CICMcMyBP-ccTnIcTNTά-tropomyosinsodium dodecyl sulfate-polyacrylamide gel electrophoresisSDS-PAGELeft ventricularCardiac biomarkerImmunoprecipitationcardiac troponin TELISAEnzyme-linked immunosorbent assayPosterior wallanterior wallPhosphate buffered salinePhosphorylationcardiac troponin Imilliliternanogramischemic cardiomyopathy
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Authors
Suresh Govindan, Andrew McElligott, Saminathan Muthusamy, Nandini Nair, David Barefield, Jody L. Martin, Enrique Gongora, Kenneth D. Greis, Pradeep K. Luther, Saul Winegrad, Kyle K. Henderson, Sakthivel Sadayappan,