| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953831 | Journal of Molecular and Cellular Cardiology | 2012 | 11 Pages |
Abstract
⺠hERG K+ channels regulate cardiac action potential repolarization. ⺠Molecular determinants of hERG block by the Class Ia antiarrhythmic disopyramide were studied. ⺠S6 helical residues Y652 and F656 contribute to disopyramide binding. ⺠Interactions with pore helical residues are not necessary for disopyramide binding.
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Authors
Aziza El Harchi, Yi H. Zhang, Leyla Hussein, Christopher E. Dempsey, Jules C. Hancox,