| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953832 | Journal of Molecular and Cellular Cardiology | 2012 | 10 Pages |
Abstract
⺠The Crataegus extract WS® 1442 protects against endothelial hyperpermeability in vivo and in vitro. ⺠WS® 1442 inhibits detrimental effects of thrombin on adherens junctions, the F-actin cytoskeleton, and the contractile apparatus. ⺠Mechanistically, WS® 1442 blocks the thrombin-induced barrier-disrupting calcium/PKC/RhoA signaling. ⺠Concurrently, WS® 1442 activates the barrier-stabilizing cAMP/Epac/Rap1 pathway. ⺠WS® 1442 opens a novel pharmacological approach to treat hyperpermeability-associated diseases.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Martin F. Bubik, Elisabeth A. Willer, Peter Bihari, Guido Jürgenliemk, Hermann Ammer, Fritz Krombach, Stefan Zahler, Angelika M. Vollmar, Robert Fürst,