Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10953850 | Journal of Molecular and Cellular Cardiology | 2011 | 13 Pages |
Abstract
⺠DDP-4 inhibitors like sitagliptin are novel drugs in type 2 diabetes therapy. ⺠Sitagliptin improves glucose tolerance and reduces weight gain in db/dbâ/â mice. ⺠Sitagliptin reduces elevated cardiac fatty acid uptake and oxidation in db/dbâ/â mice. ⺠Sitagliptin prevents myocardial fibrosis. ⺠Sitagliptin reduces AGEs and oxidative stress in cardiomyocytes of db/dbâ/â mice.
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Authors
M. Lenski, A. Kazakov, N. Marx, M. Böhm, U. Laufs,