Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A

Article ID	Journal	Published Year	Pages	File Type
10953859	Journal of Molecular and Cellular Cardiology	2011	9 Pages	PDF

Abstract

âº ISO-treated Pak-1-KO hearts are highly susceptible to cardiac hypertrophy. âº Pak-1/PP2A and Erk1/2 bind to carry out their biological function in the heart. âº Erk1/2 activation is increased in ISO-treated Pak-1-KO hearts. âº Pak-1 has an inhibitory role on Erk1/2 activation via PP2A. âº FR180204, a selective inhibitor of Erk1/2, attenuates myocardial hypertrophy in ISO-treated Pak-1-KO mice.

Keywords

LVPWd cTnI FVB Jun N-terminal kinase Jnk EDV cTNT ERK lacZ CTRL ESV EDT 2-D DIGE ISO isoproterenol Left ventricular/ventricle cardiac troponin T End-diastolic volume end-systolic volume constitutively active cardiac troponin I knockout heterozygous Control fractional shortening extracellular signal-regulated kinase

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology

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Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A

Authors

Domenico M. Taglieri, Michelle M. Monasky, Ivana Knezevic, Katherine A. Sheehan, Ming Lei, Xin Wang, Jonathan Chernoff, Beata M. Wolska, Yunbo Ke, R. John Solaro,