| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953866 | Journal of Molecular and Cellular Cardiology | 2012 | 6 Pages |
Abstract
⺠The background to the development of local control (LC) theories for cardiac excitation-contraction coupling is described. ⺠LC theories solve the problem of uncontrolled cell-wide regeneration during calcium-induced calcium release (CICR). ⺠Evidence for LC of CICR includes cytoplasmic Ca sparks and local sarcoplasmic reticulum (SR) calcium depletions ('blinks'). ⺠Termination of local CICR remains unclear and key processes contributing to stochastic attrition are discussed. ⺠Ryanodine receptor gating modulates mean SR Ca levels which may regulate other cellular functions beyond contractility.
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Authors
M.B. Cannell, Cherrie H.T. Kong,