| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953872 | Journal of Molecular and Cellular Cardiology | 2012 | 10 Pages |
Abstract
⺠Different from plasmalemmal eNOS, sarcoplasmic nNOS facilitates basal myocardial relaxation and attenuates contraction. ⺠nNOS promotes PKA-dependent phospholamban phosphorylation and inhibits L-type Ca2+ channel activity. ⺠nNOS modulates myocardial oxidases and maintains eNOS 'coupling' to produce NO. ⺠nNOS is up-regulated and translocates to sarcolemma in diseased heart and attenuates its adverse remodeling. ⺠eNOS is 'uncoupled' and contributes to oxidative stress in failing myocardium.
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Authors
Yin Hua Zhang, Barbara Casadei,