| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953876 | Journal of Molecular and Cellular Cardiology | 2012 | 12 Pages |
Abstract
⺠L-type Ca2+ channels regulate diverse cellular processes in the heart. ⺠Different L-type Ca2+ channel subpopulations exist in cardiomyocytes. ⺠Function and regulation of L-type Ca2+ channels depend on subcellular localization. ⺠Altered localization of L-type Ca2+ channels plays a role in heart disease.
Keywords
PKCαCa2+-dependent inactivationPolymerase I and transcript release factorMicrodomainPTRFT-tubulesPP2BAKAPLTCCCREBLQTSTIRFGPiSNARECaMKpKaNFATCAVCDIANPPP2AC-terminusICa,LL-type Ca2+ current[Ca2+]iCa2+-induced Ca2+ releaseFluorescence resonance energy transferFRETexcitation–contractioncarboxyl terminusSarcoplasmic reticulumCAMcongenital long QT syndromeTimothy syndromeCalcium signalingNuclear Factor of Activated T CellsCardiomyocyteTransverse tubulesSubcellular localizationA-kinase anchoring proteinprotein phosphatase 2AProtein phosphatase 2BcAMP-responsive element-binding proteinprotein kinase Aprotein kinase C alphaatrial natriuretic peptideCalmodulinL-type Ca2+ channelCalcium channeltotal internal reflection fluorescenceCICRCaveolinglycosylphosphatidyl inositolsoluble N-ethylmaleimide-sensitive factor attachment protein receptor
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Authors
Jabe M. Best, Timothy J. Kamp,