| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953879 | Journal of Molecular and Cellular Cardiology | 2012 | 9 Pages |
Abstract
⺠During metabolic impairment, a change in the ATP:ADP ratio stimulates KATP channels opening. ⺠The ATP:AMP ratio is an acquisitively sensitive indicator of alterations in the metabolic status. ⺠We show that AMP-activated protein kinase (AMPK) activity promotes KATP channel opening. ⺠AMPK physically interacts with KATP channel subunits, suggestive of local signaling. ⺠Thus, small changes in AMP may trigger KATP channel availability under ischemic conditions.
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Authors
Hidetada Yoshida, Li Bao, Eirini Kefaloyianni, Eylem Taskin, Uzoma Okorie, Miyoun Hong, Piyali Dhar-Chowdhury, Michiyo Kaneko, William A. Coetzee,