| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953884 | Journal of Molecular and Cellular Cardiology | 2012 | 10 Pages |
Abstract
⺠We determined an interaction between S100B and vascular endothelial growth factor. ⺠In rat cardiocyte cultures, S100B increased VEGF mRNA, protein, and secretion. ⺠In culture, rat cardiac fibroblasts undergo phenotypic transition to myofibroblasts. ⺠VEGF induces via VEGFR-2, ERK1/2 phosphorylation and myofibroblast proliferation. ⺠Myofibroblast proliferation contributes to scar formation in infarcted myocardium.
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Authors
James N. Tsoporis, Shehla Izhar, Gerald Proteau, Graham Slaughter, Thomas G. Parker,