| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953900 | Journal of Molecular and Cellular Cardiology | 2012 | 6 Pages |
Abstract
⺠This review describes three isoforms/splice variants of the ERG protein. ⺠ERG1b and ERGuso modulate ERG1a channel trafficking, expression and kinetics. ⺠ERG1b alters kinetics resulting in more available channels and larger current. ⺠ERGuso leads to a reduced number of channels at the plasma membrane. ⺠This has implications for cardiac disease and drug development.
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Authors
Malin K.B. Jonsson, Marcel A.G. van der Heyden, Toon A.B. van Veen,