| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953903 | Journal of Molecular and Cellular Cardiology | 2012 | 9 Pages |
Abstract
⺠First direct kinetic data of cellular ADMA uptake by CAT1 (SLC7A1) are generated. ⺠CAT1 can mediate uptake as well as efflux of ADMA. ⺠The Km value for CAT1-mediated uptake was lower for ADMA than for l-arginine. ⺠Physiological ADMA levels do not impair CAT1-mediated uptake of l-arginine and SDMA. ⺠At physiological concentrations, l-arginine inhibits CAT1-mediated uptake of ADMA.
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Authors
Joachim Strobel, Maren Mieth, Beate EndreÃ, Daniel Auge, Jörg König, Martin F. Fromm, Renke Maas,