Spatial variability in T-tubule and electrical remodeling of left ventricular epicardium in mouse hearts with transgenic Gαq overexpression-induced pathological hypertrophy

► Transgenic Gαq overexpression in the heart causes pathological LV hypertrophy. ► Transgenic Gαq hearts exhibit epicardial T-tubule and electrical remodeling. ► T-tubule remodeling includes patchy loss of tubules and gain of axial tubules. ► The LV epicardium of Gαq mice exhibits heterogeneous action potential prolongation. ► Dispersion of repolarization rises despite normal Cx43 density and distribution.