| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953908 | Journal of Molecular and Cellular Cardiology | 2012 | 9 Pages |
Abstract
⺠KATP currents are detected in embryonic cardiomyocytes since early cardiac development. ⺠Embryos overexpressing KATP demonstrate normal cardiac looping pattern. ⺠Transgenic mice overexpressing KATP channel subunits demonstrate embryonic lethality. ⺠The embryonic lethality of the KATP overexpressing embryos is a result of in utero heart failure.
Keywords
ABCDPCαSMAKATPNCXStgDTGS.E.MGFPαMHCPBSα myosin heavy chainH&Eα smooth muscle actinbpmCardiac developmentstandard error of the meanholding potentialdouble transgenicdays post conceptionbeats per minutePhosphate buffered salineEmbryonic lethalityheart failurewild typeHematoxylin and Eosingreen fluorescent proteinATP-sensitive K+ channelATP-binding cassette
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Amir Toib, Hai Xia Zhang, Thomas J. Broekelmann, Krzysztof L. Hyrc, Qiusha Guo, Feng Chen, Maria S. Remedi, Colin G. Nichols,