| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953909 | Journal of Molecular and Cellular Cardiology | 2012 | 12 Pages |
Abstract
⺠The RCM mutation R193H in troponin I decreased myocardial and myocyte compliance. ⺠R193H troponin I elevated end diastolic pressures. ⺠Sarcomere relaxation and Ca2+ decay were uncoupled in isolated R193H myocytes. ⺠Altered Ca2+ handling proteins compensated for R193H Ca2+ sensitive myofilaments.
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Authors
Jennifer Davis, Soichiro Yasuda, Nathan J. Palpant, Joshua Martindale, Tamara Stevenson, Kimber Converso, Joseph M. Metzger,