| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953923 | Journal of Molecular and Cellular Cardiology | 2012 | 9 Pages |
Abstract
⺠Extracellular matrix remodeling in an aged HF animal model remains unexplored. ⺠Gross functional and morphological LV remodeling is greatest in aged HF sheep. ⺠Collagen content is increased in young HF but decreased in aged HF. ⺠MMP activity and collagen fibrillogenesis increases in both young HF and aged HF. ⺠TIMP protein levels are diminished only in aged HF hearts.
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Authors
Margaux A. Horn, Helen K. Graham, Mark A. Richards, Jessica D. Clarke, David J. Greensmith, Sarah J. Briston, Mark C.S. Hall, Katharine M. Dibb, Andrew W. Trafford,