| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953925 | Journal of Molecular and Cellular Cardiology | 2012 | 12 Pages |
Abstract
⺠We exploited next-gen sequencing for a comprehensive cardiac mRNA and miRNA profiling. ⺠We revealed the transcriptome signature of the cardiac protective effects of PI3Kα. ⺠Increased PI3Kα signaling normalizes miRNA/mRNA expression with pathological LVH. ⺠PI3Kα reduces cardiac fibrosis through modulating TGF-β pathway and miR-21 expression. ⺠We identified multiple novel miRNAs linked to remodeling in cardiac hypertrophy.
Keywords
ANFPI3KαmRNA sequencingRPKMmRNA-SeqpMMRLVHGPCRTACqRT-PCRGAPDHFDRG-protein coupled receptorMyocardial infarctionleft ventricleTranscriptomeNext-generation sequencingtransverse aortic constrictionatrial natriuretic factorfalse discovery rateMiRNAwild-typeGene ontologyLeft ventricular hypertrophyCardiac hypertrophyquantitative real time polymerase chain reactionglyceraldehydes 3-phosphate dehydrogenase
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Authors
Kai-Chien Yang, Yuan-Chieh Ku, Michael Lovett, Jeanne M. Nerbonne,