| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10953938 | Journal of Molecular and Cellular Cardiology | 2011 | 11 Pages |
Abstract
⺠We investigated ATP-regulated potassium channels in diseased and normal human heart. ⺠Pinacidil decreased APD in atria and ventricles in all physiological states. ⺠Diazoxide decreased APD in both chambers and all states, except normal human atria. ⺠Heart failure and/or previous infarct potentiated diazoxide-induced APD shortening. ⺠Activation of human KATP channels enhances arrhythmogenicity.
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Authors
Vadim V. Fedorov, Alexey V. Glukhov, Christina M. Ambrosi, Geran Kostecki, Roger Chang, Deborah Janks, Richard B. Schuessler, Nader Moazami, Colin G. Nichols, Igor R. Efimov,